To evaluate prognostic significance of the expression of P-glycoprotein in primary cancer tissue 62 cases of gastric cancer and 40 cases of Astler-Coller modified Dukes B2 and C colorectal cancer were analyzed, p-glycoprotein. p53 protein, and PCNA were stained by immunohistochemistry. P-glycoprotein positive was defined when the tumor cells more than 10% showed red dot in the cytoplasm. In gastric cancer 33 cases(53.2%) were P-glycoprotein positive. There was no significant correlation between P-glycoprotein expression and other parameters such as age. sex, location of tumor, tumor size, gross form, histologic type, depth of invasion, lymph node metastasis, stage, p53 protein, and PCNA expression. 5 year cumulative survival rate of P-glycoprotein positive group 54.6% was higher than negative group 27.6% (P<0.05). but there was no difference in comparison groups in the same stage. In colorectal cancer 15 cases (37.5%) were P-glycoprotein positive. There was no significant correlation between P-glycoprotein and other parameters such as age, sex. location of tumor, tumor size, histologic type, and stage. 5 year cumulative survival rate of p-glycoprotein negative group 84.0% was higher than positive group 66.7% (P<0.05), but there was no difference in comparison in the same stage.
The above results indicate that P-glycoprotein has an some prognostic significance in gastric and colorectal cancer.
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